HER2 Support Group Forums - View Single Post - Watery eyes and red eyelids-Herceptin?

Darlene Denise · 07-25-2009, 06:49 PM

Dianne: Maybe your onc should actually read the full prescribing information that comes packaged with the Herceptin. As you will note, rhinitis is an adverse reaction and it is contributing to the watery eyes. I have a suggestion:

If you are not being premedicated with Benadryl prior to infusion, try that since it is an antihistamine. Then maybe take the Benadryl for a day or so after.

Here's the supporting info for you and your onc and I hope this helps solve your mystery and you find some relief.

HIGHLIGHTS OF PRESCRIBING INFORMATION
These highlights do not include all the information needed to use Herceptin safely and effectively. See full prescribing information for Herceptin.
HERCEPTIN® (trastuzumab) Intravenous Infusion

Table 3 Adverse Reactions for Study 3, All Gradesa:

MedDRA (v. 7.1) Adverse Event Preferred Term

1 Year Herceptin (n= 1678)

Observation (n=1708)

Cardiac
Hypertension

64 (4%)

35 (2%)

Dizziness

60 (4%)

29 (2%)

Ejection Fraction Decreased

58 (3.5%)

11 (0.6%)

Palpitations

48 (3%)

12 (0.7%)

Cardiac Arrhythmiasb

40 (3%)

17 (1%)

Cardiac Failure Congestive

30 (2%)

5 (0.3%)

Cardiac Failure

9 (0.5%)

4 (0.2%)

Cardiac Disorder

5 (0.3%)

0 (0%)

Ventricular Dysfunction

4 (0.2%)

0 (0%)

Respiratory Thoracic Mediastinal Disorders
Nasopharyngitis

135 (8%)

43 (3%)

Cough

81 (5%)

34 (2%)

Influenza

70 (4%)

9 (0.5%)

Dyspnea

57 (3%)

26 (2%)

URI

46 (3%)

20 (1%)

Rhinitis

36 (2%)

6 (0.4%)

Pharyngolaryngeal Pain

32 (2%)

8 (0.5%)

Sinusitis

26 (2%)

5 (0.3%)

Allergic rhinitis involves inflammation of the mucous membranes of the nose, eyes, eustachian tubes, middle ear, sinuses, and pharynx. The mediators that are immediately released include histamine, tryptase, chymase, kinins, and heparin.7,8 The mast cells quickly synthesize other mediators, including leukotrienes and prostaglandin D2.9,10,11 These mediators, via various interactions, ultimately lead to the symptoms of rhinorrhea (ie, nasal congestion, sneezing, itching, redness, tearing, swelling, ear pressure, postnasal drip). Mucous glands are stimulated, leading to increased secretions

07-25-2009, 06:49 PM	#23
Darlene Denise Senior Member Join Date: Aug 2008 Location: Virginia Beach, Virginia Posts: 145	The Eyes Have IT! Dianne: Maybe your onc should actually read the full prescribing information that comes packaged with the Herceptin. As you will note, rhinitis is an adverse reaction and it is contributing to the watery eyes. I have a suggestion: If you are not being premedicated with Benadryl prior to infusion, try that since it is an antihistamine. Then maybe take the Benadryl for a day or so after. Here's the supporting info for you and your onc and I hope this helps solve your mystery and you find some relief. HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use Herceptin safely and effectively. See full prescribing information for Herceptin. HERCEPTIN® (trastuzumab) Intravenous Infusion Table 3 Adverse Reactions for Study 3, All Gradesa: MedDRA (v. 7.1) Adverse Event Preferred Term 1 Year Herceptin (n= 1678) Observation (n=1708) Cardiac Hypertension 64 (4%) 35 (2%) Dizziness 60 (4%) 29 (2%) Ejection Fraction Decreased 58 (3.5%) 11 (0.6%) Palpitations 48 (3%) 12 (0.7%) Cardiac Arrhythmiasb 40 (3%) 17 (1%) Cardiac Failure Congestive 30 (2%) 5 (0.3%) Cardiac Failure 9 (0.5%) 4 (0.2%) Cardiac Disorder 5 (0.3%) 0 (0%) Ventricular Dysfunction 4 (0.2%) 0 (0%) Respiratory Thoracic Mediastinal Disorders Nasopharyngitis 135 (8%) 43 (3%) Cough 81 (5%) 34 (2%) Influenza 70 (4%) 9 (0.5%) Dyspnea 57 (3%) 26 (2%) URI 46 (3%) 20 (1%) Rhinitis 36 (2%) 6 (0.4%) Pharyngolaryngeal Pain 32 (2%) 8 (0.5%) Sinusitis 26 (2%) 5 (0.3%) Allergic rhinitis involves inflammation of the mucous membranes of the nose, eyes, eustachian tubes, middle ear, sinuses, and pharynx. The mediators that are immediately released include histamine, tryptase, chymase, kinins, and heparin.7,8 The mast cells quickly synthesize other mediators, including leukotrienes and prostaglandin D2.9,10,11 These mediators, via various interactions, ultimately lead to the symptoms of rhinorrhea (ie, nasal congestion, sneezing, itching, redness, tearing, swelling, ear pressure, postnasal drip). Mucous glands are stimulated, leading to increased secretions __________________ 12/14/07 IDC ER- PR- HER2+++ LIVER METS AT DX CONFIRMED BY LIVER BIOPSY 01/14/08 2 AC TREATMENTS-NOT WORKING 02/04/08 13 TAXOL, CARBO, HERCEPTIN TREATMENT-EXCELLENT RESULTS! 05/12/08 HERCEPTIN EVERY 3 WKS 08/22/08 BRAIN METS! 8 <5MM 09/17/08 CYBERKNIFED BRAIN METS 10/20/08 BRAIN METS SHRINKING 12/29/08 BRAIN SCAN SHOWS 1 LESION GONE, 7 SHRINKING & STABLE, 1MM ? SPOT 01/16/09 LIVER REOCUR-XELODA/HERCEPTIN 03/02/09 BRAIN SCAN 2 LESIONS GONE, 5 STABLE, 1MM ? SPOT STILL A ? 3/27/09 REGRESSION OF 2 LIVER LESIONS XELODA & HERCEPTIN 06/08/09 STUPID BRAIN HAS 3 LESIONS 06/29/09 CYBERKNIFE 07/01/09 LIVER REGRESSION NO NEW METS 07/07/09 TYKERB XELODA HERCEPTIN 11/11/09 GEMZAR/HERCEPTIN FOR LIVER PROGRESSION 03/22/10 BRAIN MRI GOOD-3 SMALL NECROSIS LEFT FROM ORIG 11!! 03/26/10 CHANGE TO NAVELBINE/HERCEPTIN 3 LIVER LESIONS PROGRESSING IN SIZE 05/21/10 NAVELBINE/HERCEPTIN WORKING! 07/19/10 GOOD BRAIN MRI 08/20/10 LIVER PROGRESSION 09/08/10 TDM1 - NASHVILLE TN 01/10/11 LIVER RESPONDING TO TDM1