[Eva Sophia]

I have been on the Marianne study - TDM-1 plus/minus pertuzumab since April 2011 - 22months. I think that puts me at about 30 doses. Overall, I've been very good on it - with no nausea, hair loss at all. The fatigue has become an issue, particularly since month 19. I also developed a blood disorder around month 3. It appeared as a "rash" which has been diagnosed as telangectasias (broken capillary vessels) all over my chest and hands and on my face as well. Also, I bleed very easily, like my blood is thin and doesn't clot well. They ran a whole series of tests that show that I do clot, but just not normally.

Since you asked, here are my abnormal lab results from my last draw on Monday - they have all been very stable throughout.
Hemoglobin 10.3
Hematocrit 31.5
RDW 18.9
%Monocytes 18.2
Albumin 3.8
ALT 82
AST 107

I hope that helps. Would love to hear from others who have bleeding issues or fatigue after a long time on TDM-1.

I have been NED since my very first scan after getting on the drug!