HER2 Support Group Forums - View Single Post - Tch after-effects?

Debbie L. · 04-05-2009, 09:17 AM

However, it does mention cisplatin which I assume is related to carbo:

http://cancerres.aacrjournals.org/cg...act/62/10/2771

Last bit:
"A combination of cisplatin and ifosfamide, two drugs that are widely used in the treatment of cancer patients, also depressed the expression of proteasomal subunits in muscles from rats bearing the MatB adenocarcinoma below basal levels. Thus, a down-regulation of ubiquitin-proteasome-dependent proteolysis is observed with various cytostatic agents and contributes to reverse the chemotherapy-induced muscle wasting."

Debbie

04-05-2009, 09:17 AM	#5
Debbie L. Senior Member Join Date: Jul 2006 Posts: 463	one small reference but it's not the one I was looking for However, it does mention cisplatin which I assume is related to carbo: http://cancerres.aacrjournals.org/cg...act/62/10/2771 Last bit: "A combination of cisplatin and ifosfamide, two drugs that are widely used in the treatment of cancer patients, also depressed the expression of proteasomal subunits in muscles from rats bearing the MatB adenocarcinoma below basal levels. Thus, a down-regulation of ubiquitin-proteasome-dependent proteolysis is observed with various cytostatic agents and contributes to reverse the chemotherapy-induced muscle wasting." Debbie