HER2 Support Group Forums - View Single Post - The traditional diet of Greece and cancer.

R.B. · 07-01-2006, 07:34 AM

This post is out on a limb as I have not seen it suggested any where as cancer treatment adjunct but would have grounds for consideration if one takes the stance that the omega three six balance is relevant.

Thought provoking article.

An interesting area for a trial, or consideration by those running out of options.

One for discussion with your onc????

RB

http://www.jimmunol.org/cgi/content/full/171/9/4837

ABSTRACT from full trial write up

"Potential impact of {omega}-3 fatty acids, as contained in fish oil, on immunological function has been suggested because observations of reduced inflammatory diseases in Greenland Inuit were published. A fish oil-based lipid emulsion has recently been approved for parenteral nutrition in many countries. We investigated the influence of a short infusion course of fish oil-based ({omega}-3) vs conventional ({omega}-6) lipid emulsion on monocyte function. In a randomized design, twelve healthy volunteers received {omega}-3 or {omega}-6 lipid infusion for 48 h, with cross-over repetition of the infusion course after 3 mo. Fatty acid profiles, monocyte cytokine release and adhesive monocyte-endothelium interaction were investigated. Resultant {omega}-6 lipid emulsion increased plasma-free fatty acids including arachidonic acid, whereas the {omega}-3/{omega}-6 fatty acid ratio in monocyte membranes remained largely unchanged. It also caused a tendency toward enhanced monocyte proinflammatory cytokine release and adhesive monocyte-endothelium interaction. In contrast, {omega}-3 lipid emulsion significantly increased the {omega}-3/{omega}-6 fatty acid ratio in the plasma-free fatty acid fraction and in monocyte membrane lipid pool, markedly suppressing monocyte generation of TNF-{alpha}, IL-1, IL-6, and IL-8 in response to endotoxin. In addition, it also significantly inhibited both monocyte-endothelium adhesion and transendothelial monocyte migration, although monocyte surface expression of relevant adhesive molecules (CD11b, CD18, CD49 days, CCR2) was unchanged. Although isocaloric, {omega}-3 and {omega}-6 lipid emulsions exert differential impact on immunological processes in humans. In addition to its nutritional value, fish oil-based {omega}-3 lipid emulsion significantly suppresses monocyte proinflammatory cytokine generation and features of monocyte recruitment."

07-01-2006, 07:34 AM	#17
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Guesswork and out on a limb fish oil-derived {omega}-3 lipid-based emulsions Infusion This post is out on a limb as I have not seen it suggested any where as cancer treatment adjunct but would have grounds for consideration if one takes the stance that the omega three six balance is relevant. Thought provoking article. An interesting area for a trial, or consideration by those running out of options. One for discussion with your onc???? RB http://www.jimmunol.org/cgi/content/full/171/9/4837 ABSTRACT from full trial write up "Potential impact of {omega}-3 fatty acids, as contained in fish oil, on immunological function has been suggested because observations of reduced inflammatory diseases in Greenland Inuit were published. A fish oil-based lipid emulsion has recently been approved for parenteral nutrition in many countries. We investigated the influence of a short infusion course of fish oil-based ({omega}-3) vs conventional ({omega}-6) lipid emulsion on monocyte function. In a randomized design, twelve healthy volunteers received {omega}-3 or {omega}-6 lipid infusion for 48 h, with cross-over repetition of the infusion course after 3 mo. Fatty acid profiles, monocyte cytokine release and adhesive monocyte-endothelium interaction were investigated. Resultant {omega}-6 lipid emulsion increased plasma-free fatty acids including arachidonic acid, whereas the {omega}-3/{omega}-6 fatty acid ratio in monocyte membranes remained largely unchanged. It also caused a tendency toward enhanced monocyte proinflammatory cytokine release and adhesive monocyte-endothelium interaction. In contrast, {omega}-3 lipid emulsion significantly increased the {omega}-3/{omega}-6 fatty acid ratio in the plasma-free fatty acid fraction and in monocyte membrane lipid pool, markedly suppressing monocyte generation of TNF-{alpha}, IL-1, IL-6, and IL-8 in response to endotoxin. In addition, it also significantly inhibited both monocyte-endothelium adhesion and transendothelial monocyte migration, although monocyte surface expression of relevant adhesive molecules (CD11b, CD18, CD49 days, CCR2) was unchanged. Although isocaloric, {omega}-3 and {omega}-6 lipid emulsions exert differential impact on immunological processes in humans. In addition to its nutritional value, fish oil-based {omega}-3 lipid emulsion significantly suppresses monocyte proinflammatory cytokine generation and features of monocyte recruitment." Last edited by R.B.; 06-28-2009 at 04:41 AM..