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R.B. · 11-22-2013, 03:54 PM

http://jcem.endojournals.org/content/94/5/1683.long

Title
Thyroid function in early pregnancy in Japanese healthy women: relation to urinary iodine excretion, emesis, and fetal and child development.

Journal
Journal of Clinical Endocrinology & Metabolism 2009 Vol. 94 No. 5 pp. 1683-1688

Abstract

Context: The effect of constant rich iodine intake, especially during pregnancy, has not been well understood. Objective: The objective was to examine urinary iodine excretion and thyroid function in early pregnancy in Japanese healthy women. We also studied fetal maturation and child development in these women. Design and Setting: This study was an observational, prospective study conducted at a maternity hospital. Subjects: Subjects were 622 pregnant women who visited a maternity hospital consecutively in early gestation. Subjects with positive thyroid antibodies were excluded, and finally 514 subjects were examined. Offspring subjects were infants born to the maternal subjects. Main Outcome Measures: Thyroid function, serum thyroperoxidase antibodies, and urinary concentrations of iodine were measured at the initial obstetrical visit. The fetal maturation scores estimated by the Dubowitz and Ballard methods in newly born infants were assessed. A child developmental test was performed using the Enjoji Scale up to 12 months of age. Results: The distribution of urinary iodine concentrations was large, and the average was extremely high. There were significant positive correlations between urinary iodine and serum TSH (r=0.1326; P<0.005). Serum TSH during early pregnancy in mothers had no relevance to parameters in neonates, scores of fetal maturation, or child developmental testing in their infants. Conclusions: Iodine excess during early pregnancy seems to have no adverse effects on the fetus in healthy Japanese women. To avoid hypothyroidism, reducing excess dietary iodine intake to moderate intake may be beneficial for pregnant woman in Japan.

The official Japanese recommendation appears to be 3mg; the chart of urinary iodine shows intakes ranged widely and some were very high.

"Considering all the various factors together, the limit of iodine intake for healthy Japanese pregnant women should be around 3000 μg iodine/d, as recommended by the Japanese Health, Labor and Welfare Ministry (9)."

11-22-2013, 03:54 PM	#85
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo http://jcem.endojournals.org/content/94/5/1683.long Title Thyroid function in early pregnancy in Japanese healthy women: relation to urinary iodine excretion, emesis, and fetal and child development. Journal Journal of Clinical Endocrinology & Metabolism 2009 Vol. 94 No. 5 pp. 1683-1688 Abstract Context: The effect of constant rich iodine intake, especially during pregnancy, has not been well understood. Objective: The objective was to examine urinary iodine excretion and thyroid function in early pregnancy in Japanese healthy women. We also studied fetal maturation and child development in these women. Design and Setting: This study was an observational, prospective study conducted at a maternity hospital. Subjects: Subjects were 622 pregnant women who visited a maternity hospital consecutively in early gestation. Subjects with positive thyroid antibodies were excluded, and finally 514 subjects were examined. Offspring subjects were infants born to the maternal subjects. Main Outcome Measures: Thyroid function, serum thyroperoxidase antibodies, and urinary concentrations of iodine were measured at the initial obstetrical visit. The fetal maturation scores estimated by the Dubowitz and Ballard methods in newly born infants were assessed. A child developmental test was performed using the Enjoji Scale up to 12 months of age. Results: The distribution of urinary iodine concentrations was large, and the average was extremely high. There were significant positive correlations between urinary iodine and serum TSH (r=0.1326; P<0.005). Serum TSH during early pregnancy in mothers had no relevance to parameters in neonates, scores of fetal maturation, or child developmental testing in their infants. Conclusions: Iodine excess during early pregnancy seems to have no adverse effects on the fetus in healthy Japanese women. To avoid hypothyroidism, reducing excess dietary iodine intake to moderate intake may be beneficial for pregnant woman in Japan. The official Japanese recommendation appears to be 3mg; the chart of urinary iodine shows intakes ranged widely and some were very high. "Considering all the various factors together, the limit of iodine intake for healthy Japanese pregnant women should be around 3000 μg iodine/d, as recommended by the Japanese Health, Labor and Welfare Ministry (9)." Last edited by R.B.; 11-22-2013 at 04:02 PM..