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Old 06-13-2018, 11:16 PM   #4
Pamelamary
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Join Date: Apr 2012
Location: Melbourne, Australia
Posts: 494
Re: Treatment after Kadcyla?

Hi Juls,
Sorry to hear this. Might be an idea to find out about what trials are available. I have heard of promising results from Herceptin + Keytruda, and there is some new formulation of Herceptin - trastuzumab deruxtecan (a bit like Kadcyla). Also Ont 380 and Margetuxumab - probably still at trial stage. I wonder if Tykerb is being used much now? These are all Her2+, and I guess there are plenty of non-targeted options. Bewildering, but good luck with finding a new treatment plan.
Best wishes.... Pam
__________________
Diagnosed 2004: Lumpectomy - 2 tumours, both grade 1 infiltrating duct carcinoma, about 12mm. ER+,
C-erbB-2 status 3+.
Clear margins, no nodal involvement.
Radiotherapy, i year Tamoxifen, 4 years Arimidex.
Rediagnosed 2012: Multiple bone metastases.
3/12: began on Marianne trial - T-DM1 + Pertuzamab/Placebo.
5/12:Unexpected development of numerous bilateral liver mets. Came off trial.
Started Docetaxol/ Herceptin + Zometa.
8/12:Bones stable +major regression in liver (!)
9/12:Can't take any more Docetaxol! Start on Herceptin and Tamoxifen. Cross fingers!
Changed to Denosumab.
11/12: Scan shows stable - yay!
11/13: Still stable :-) !!!
1/16: All stable, but lowered calcium, so switched to Zometa 3 monthly.
2/19: Happily still stable on Herceptin, Letrozole and 3 monthly Zometa.
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