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Rich66 · 10-11-2009, 02:20 PM

October 08, 2009

Clinical Trials for White blood cell infusions to treat cancer

The Wake Forest Clinical trial for granulocyte infusions to cure cancer was cancelled but a new South Florida clinical trial is proceeding. The clinical trials are to see if simple blood transfusions can transfer cancer immunity from people with strong cancer immunity to those without such strong immunity. This procedure has been shown to cure cancer in mice. A mouse is given a lot of cancer and then is cured of it with blood transfusions from super-immune mice.
Here is the link to the cancelled clinical trial.

South Florida Bone Marrow/Stem Cell Transplant Institute is sponsoring the white blood cell transfusion clinical trial. The phase I and II trial that is running now.

>South Florida Bone Marrow/Stem Cell Transplant Institute page on the granulocyte anti-cancer clinical trial

The South Florida Institute information page for cancer patients cites the Wake Forest work and history of the project.

Link to the institute's home page and tv news clip: http://www.bmscti.org/index.htm

This is the cancer treatment from Zheng Cui, which has been covered extensively at this site.
Update on the GIFT cancer treatment

White blood cells from a strain of cancer-resistant mice cured advanced cancers in ordinary laboratory mice, researchers at Wake Forest University School of Medicine reported

at the SENS3 conference in Sept 2007, Dr. Cui presented the next logical step in his research: work demonstrating the existence of, and characterizing, high-potency cancer-killing granulocytes in humans. This same cancer killing cells provides mice with immunity to cancer.

A Phase I/II Study For the Use of White Blood Cells From Healthy Donor-Participants To Treat Subjects With Solid Cancers

http://clinicaltrials.gov/ct2/show/NCT00900497

About 75% of US population living today will not die of cancer. It is not uncommon that some people remain cancer-free into their 80s and 90s, even if they are regularly exposed to environmental carcinogens such as air pollutants, cigarette smoking, etc. A frequently asked but unanswered question is why these individuals do not get cancer. There has been a recent report of a colony of cancer-resistant mice developed from a single male mouse that unexpectedly survived challenges of lethal cancer cell injections. In these so-called spontaneous regression/complete resistant (SR/CR) mice, cancer cells are killed by rapid infiltration of leukocytes, mainly of innate immunity. This highly effective natural cancer immunity is inherited and mediated entirely by white blood cells. Moreover, this cancer resistance can be transferred to wild type mice through the transfer of various immune cell types including granulocytes.

This observation raises the possibility that infusion of white blood cells, particularly cells of innate immunity, is a viable anticancer therapy in humans as well.

This proposed trial will test whether white blood cell infusions from healthy unrelated donors can be used to treat cancer. The trial is designed to determine whether responses can be seen in cancer patients after infusion of HLA-mismatched white cells from healthy donors. It is important that the donors and recipients be unrelated and HLA-mismatched to avoid the possibility of transfusion-related Graft vs. Host Disease.

10-11-2009, 02:20 PM	#1
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	LIFT (leukocyte infusion therapy) October 08, 2009 Clinical Trials for White blood cell infusions to treat cancer The Wake Forest Clinical trial for granulocyte infusions to cure cancer was cancelled but a new South Florida clinical trial is proceeding. The clinical trials are to see if simple blood transfusions can transfer cancer immunity from people with strong cancer immunity to those without such strong immunity. This procedure has been shown to cure cancer in mice. A mouse is given a lot of cancer and then is cured of it with blood transfusions from super-immune mice. Here is the link to the cancelled clinical trial. South Florida Bone Marrow/Stem Cell Transplant Institute is sponsoring the white blood cell transfusion clinical trial. The phase I and II trial that is running now. >South Florida Bone Marrow/Stem Cell Transplant Institute page on the granulocyte anti-cancer clinical trial The South Florida Institute information page for cancer patients cites the Wake Forest work and history of the project. Link to the institute's home page and tv news clip: http://www.bmscti.org/index.htm This is the cancer treatment from Zheng Cui, which has been covered extensively at this site. Update on the GIFT cancer treatment White blood cells from a strain of cancer-resistant mice cured advanced cancers in ordinary laboratory mice, researchers at Wake Forest University School of Medicine reported at the SENS3 conference in Sept 2007, Dr. Cui presented the next logical step in his research: work demonstrating the existence of, and characterizing, high-potency cancer-killing granulocytes in humans. This same cancer killing cells provides mice with immunity to cancer. A Phase I/II Study For the Use of White Blood Cells From Healthy Donor-Participants To Treat Subjects With Solid Cancers http://clinicaltrials.gov/ct2/show/NCT00900497 About 75% of US population living today will not die of cancer. It is not uncommon that some people remain cancer-free into their 80s and 90s, even if they are regularly exposed to environmental carcinogens such as air pollutants, cigarette smoking, etc. A frequently asked but unanswered question is why these individuals do not get cancer. There has been a recent report of a colony of cancer-resistant mice developed from a single male mouse that unexpectedly survived challenges of lethal cancer cell injections. In these so-called spontaneous regression/complete resistant (SR/CR) mice, cancer cells are killed by rapid infiltration of leukocytes, mainly of innate immunity. This highly effective natural cancer immunity is inherited and mediated entirely by white blood cells. Moreover, this cancer resistance can be transferred to wild type mice through the transfer of various immune cell types including granulocytes. This observation raises the possibility that infusion of white blood cells, particularly cells of innate immunity, is a viable anticancer therapy in humans as well. This proposed trial will test whether white blood cell infusions from healthy unrelated donors can be used to treat cancer. The trial is designed to determine whether responses can be seen in cancer patients after infusion of HLA-mismatched white cells from healthy donors. It is important that the donors and recipients be unrelated and HLA-mismatched to avoid the possibility of transfusion-related Graft vs. Host Disease.