HER2 Support Group Forums - View Single Post - turning off p53 gene in mice regressed cancer

R.B. · 05-10-2007, 02:05 AM

Here are two abstracts suggesting DHA pushes up P53. I think I have seen more but do not recall exactly where at the moment.

RB

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

"Our results indicate the chemopreventive effect of fish oil (Maxepa) on DMBA-induced rat mammary carcinogenesis. Administration of fish oil further showed a prominent reduction of cell proliferation (24.34%, P = 0.001); DPCs (25%, P < 0.001) and an increased expression of p53 protein (4.636 +/- 0.19, P < 0.001) in preneoplastic mammary tissue when compared to carcinogen control counterpart. Histopathological and morphological analyses were carried out as end-point biomarkers. Conclusions: Our study thus provides evidence for the anticarcinogenic effect of fish oil (Maxepa) in limiting mammary preneoplasia in Sprague-Dawley rats."

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

"It was interesting to note that these agents activated both HSP70 and p53 proteins."

05-10-2007, 02:05 AM	#2
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Here are two abstracts suggesting DHA pushes up P53. I think I have seen more but do not recall exactly where at the moment. RB http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum "Our results indicate the chemopreventive effect of fish oil (Maxepa) on DMBA-induced rat mammary carcinogenesis. Administration of fish oil further showed a prominent reduction of cell proliferation (24.34%, P = 0.001); DPCs (25%, P < 0.001) and an increased expression of p53 protein (4.636 +/- 0.19, P < 0.001) in preneoplastic mammary tissue when compared to carcinogen control counterpart. Histopathological and morphological analyses were carried out as end-point biomarkers. Conclusions: Our study thus provides evidence for the anticarcinogenic effect of fish oil (Maxepa) in limiting mammary preneoplasia in Sprague-Dawley rats." http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum "It was interesting to note that these agents activated both HSP70 and p53 proteins."