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agness · 11-04-2015, 06:16 AM

This is not about brain mets but about radiation-induced changes in primary brain cancer and notes that arteriol venous malformations (slightly different blood vessels than normal) seems to increase the risk of this developing post SRS. Since I am having adjacent swelling in my cerebellum with no symptoms we are doing watchful waiting for a few weeks as its either atypical swelling or atypical leptomeningeal disease -- nice options, eh?

"Radiation effects have generally been divided into acute, subacute, and chronic phases [16]. The acute phase is first 2 months following irradiation, the subacute occurs from 2 to 6 months, and the chronic is after 6 months."

"20 Gy or more for the targeted lesion. One possible explanation is that hemodynamic changes result from changes to AVM vessels [9]. Two patients with AVM in the present study exhibited new lesions when shrinkage of AVMs was seen following STI. Generally, complete obliteration of cerebral AVM can occur from 4 months to 5 years after SRS"

Radiation-induced changes in the brain following stereotactic irradiation evaluated by sequential MRI (2004)
http://www.sciencedirect.com/science...72349604000198

11-04-2015, 06:16 AM	#33
agness Senior Member Join Date: Aug 2014 Location: Seattle, WA Posts: 285	Re: Compiling Data on HER2 Brain Mets This is not about brain mets but about radiation-induced changes in primary brain cancer and notes that arteriol venous malformations (slightly different blood vessels than normal) seems to increase the risk of this developing post SRS. Since I am having adjacent swelling in my cerebellum with no symptoms we are doing watchful waiting for a few weeks as its either atypical swelling or atypical leptomeningeal disease -- nice options, eh? "Radiation effects have generally been divided into acute, subacute, and chronic phases [16]. The acute phase is first 2 months following irradiation, the subacute occurs from 2 to 6 months, and the chronic is after 6 months." "20 Gy or more for the targeted lesion. One possible explanation is that hemodynamic changes result from changes to AVM vessels [9]. Two patients with AVM in the present study exhibited new lesions when shrinkage of AVMs was seen following STI. Generally, complete obliteration of cerebral AVM can occur from 4 months to 5 years after SRS" Radiation-induced changes in the brain following stereotactic irradiation evaluated by sequential MRI (2004) http://www.sciencedirect.com/science...72349604000198 __________________ Dx 2/14 3b HER2+/HR- left breast, left axilla, internal mammary node (behind breast bone). Neoadjuvant TCHP 3/14-7/2. PCR 8/14 LX and SND. 10/21-12/9 Proton therapy to chest wall. Dx 7/20/15 cerebellar met 3.5x5cm HER2+/HR-/GATA3+ 7/23/15 Craniotomy. 7/29/15 bone scan clear. 8/3/15 PET clean scan. LINAC SRS (5 fractions) Sept 2015. 9/17/15 CSF NED, 9/24/15 CSF NED, 11/2/15 CSF NED. 10/27/15 atypical uptake in right cerebellum - inflammation? 12/1/15 Leptomeningeal dx. Starting IT Herceptin. 1/16 - 16 fractions of tomotherapy to cerebellum, break of IT Herceptin during rads, resume at 100 mg weekly 3/2016 - stable scan 5/2016 stable scan 7/2016 pseudoprogression? 9/2016 more LM, start new chemo protocol and IV therapy treatment with HBOT 11/2016 Cyberknife to temporal lobe, HBOT just prior 12/2016 - lesions starting to show shrinkage 8/2017 - Stable since Dec 2016. Temporal lobe lesion gone. Using TCM, naturopathic oncology, physical therapy, chiro, massage, medical qigong, and energetic healing modalities in tandem. Stops at nothing. Mother of 2 boys - ages 7 and 10 (8/2017) and a lovely partner with lots to live for.