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The updated results of the trial using AC followed by TH vs TCH vs AC followed by T is showing that the 2 Herceptin arms are coming together and there is no statistical advantage of AC followed by TH over TCH (and the survival and recurrence rates are running the same in these 2 arms over no Herceptin).
I saw this presentation personally given and Dr. Slamon is rethinking this Top 2A association. Secondly, it is being rethought because there were 4 cases of AML in the AC arms and none in the TCH arms.
In this and various other papers, adriamycin may be meeting its end. Although it works well in Her2 cancers, the addition of Herceptin to less heart toxic regimes is working out well (less heart effects in the TCH arm too).
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Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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