HER2 Support Group Forums - View Single Post - DCIS & Neoadjuvant treatment

'lizbeth · 12-08-2013, 11:48 AM

I read further into the guidelines and found with breast conserving therapy a study of 215 patients showed an 8 year recurrence rate of 0% for low risk DICS, 21.5% for intermediate risk DCIS and 32.1% for high-risk DCIS.

A different study showed a 94% disease free survival rates with low risk DCIS, and 83% for both intermediate and high-risk DCIS over 10 years.

Later in the guidelines it states half of the local recurrences will be Invasive Ductal Carcinoma.

I did not see data on DCIS treated with mastectomy for recurrence rates in the guidelines.

Based on these numbers - if the goal to reduce recurrence perhaps Herceptin could make it into the guidelines. The studies will be worth watching.

I saw that IDC was found in 25% of the DCIS biopsies.

I think Sarah's decision for mastectomy was prudent, and not extreme - especially with intermediate and high risk DCIS.

12-08-2013, 11:48 AM	#25
'lizbeth Senior Member Join Date: Apr 2008 Location: Sunny San Diego Posts: 2,214	Re: DCIS & Neoadjuvant treatment - moving discussion to a new thread I read further into the guidelines and found with breast conserving therapy a study of 215 patients showed an 8 year recurrence rate of 0% for low risk DICS, 21.5% for intermediate risk DCIS and 32.1% for high-risk DCIS. A different study showed a 94% disease free survival rates with low risk DCIS, and 83% for both intermediate and high-risk DCIS over 10 years. Later in the guidelines it states half of the local recurrences will be Invasive Ductal Carcinoma. I did not see data on DCIS treated with mastectomy for recurrence rates in the guidelines. Based on these numbers - if the goal to reduce recurrence perhaps Herceptin could make it into the guidelines. The studies will be worth watching. I saw that IDC was found in 25% of the DCIS biopsies. I think Sarah's decision for mastectomy was prudent, and not extreme - especially with intermediate and high risk DCIS.