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chrisy · 07-23-2009, 11:50 AM

Ellie,

Back to your original questions, Kim was correct

In the Phase I/II trials, there were 2 dosing schedules. Either weekly or every 3 weeks. In either protocol adjustments were needed (skip a week on the weekly trial, or go to every 4 weeks instead of 3) for some people due to side effects (low platelets or high liver function tests, etc.). I have not seen any efficacy comparisons on if one was "better" than the other - too soon for that.

The most common problematic side effects include low platelets (which recover quickly for most people) and elevated liver enzymes. I also have a mild "flu like" reaction (fever, headache) and mild neuropathy. Overall it's much more easily tolerated than chemo, but tougher than plain Herceptin. You do not lose your hair on this therapy.

Efficacy has been good statistically - in the trial results that have been reported, many of the people had been "heavily pretreated" meaning multiple chemos, herceptin and tykerb. So 40% response rate in this population is really good.

07-23-2009, 11:50 AM	#6
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	Ellie, Back to your original questions, Kim was correct In the Phase I/II trials, there were 2 dosing schedules. Either weekly or every 3 weeks. In either protocol adjustments were needed (skip a week on the weekly trial, or go to every 4 weeks instead of 3) for some people due to side effects (low platelets or high liver function tests, etc.). I have not seen any efficacy comparisons on if one was "better" than the other - too soon for that. The most common problematic side effects include low platelets (which recover quickly for most people) and elevated liver enzymes. I also have a mild "flu like" reaction (fever, headache) and mild neuropathy. Overall it's much more easily tolerated than chemo, but tougher than plain Herceptin. You do not lose your hair on this therapy. Efficacy has been good statistically - in the trial results that have been reported, many of the people had been "heavily pretreated" meaning multiple chemos, herceptin and tykerb. So 40% response rate in this population is really good. __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure