[Becky]

Oh Flori

I am so sorry you are feeling bad. The side effects you are suffering from are probably cumulative from the length of time taking the meds in your treatment plan.

I would review each symptom versus each medication you are taking. Then you and your onc can decide what is best to do.

For example, Avastin causes high blood pressure and headaches while the Tykerb causes the diarrhea (and hence is probably contributing to the dehydration).

I think that eliminating just one drug at a time and see how you feel over a couple weeks might be the way to go. For example, eliminating the Avastin may cause the headaches and blood pressure concerns to subside. If over a month that doesn't happen, then another plan needs to be undertaken. I would be hesitant to take away Herceptin or Tykerb first because you are Her2 and they are anti-Her2 (and the Tykerb may be stabilizing the brain met). Perhaps taking Avastin away may make you well enough to take 4 or 5 Tykerb per day after a month's time or so.

I would recommend trying to do without a drug for a couple of weeks and see how you feel before changing up everything. If your onc wants to change up everything, you can still try an elimination plan and wait a couple of weeks while investigating and pondering your doctor's ideas.

You are an inspiration to all of us and I know you will find yourself in a good place again.

Huge hug to you.