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Old 05-21-2010, 08:05 AM   #25
fullofbeans
Senior Member
 
Join Date: Jan 2007
Location: UK
Posts: 617
Re: Bad news, no longuer NED

Thank you all, and for your feedback no need to tell you the thought of more chemo with possibly just a little extra few % improval of desease free I am not sure,obviously part of me is feeling a bit defeated at the moment.. but still trying to take control and yes as you can imagine I am doing a lot of reading at the mo found this about the benefit of radiation:

http://www.thefreelibrary.com/Isolat...r.-a0106940927

"The distant disease-free survival rate was somewhat better for the 25 patients who underwent radiotherapy as part of the treatment for supraclavicular recurrence than it was for the 17 patients who did not receive radiotherapy (P = .06). When the 8 patients who had received axillary and supraclavicular radiotherapy as part of their initial treatment were excluded, the difference became more dramatic (P = .002). Thus, the experience from this community setting indicates that isolated supraclavicular recurrence occurs uncommonly, but when it does, it is an indicator of soon-to-develop distant metastases. The overall local control rate is quite high with radiotherapy[....]he data in this report from The Netherlands indicate that local control can be achieved by radiation therapy, but the numbers were too small to demonstrate any survival advantage by additional chemotherapy. Chemotherapy or hormonal therapy alone was less likely to produce local control. "

Jessica what when and with what were your supraclav treated..?
__________________

35 y/o
June 06: BC stage I
Grade 3; ER/PR neg
Her-2+++; lumpectomies

Aug 06: Stage IV
liver mets: 6 tumours
July 06 to Jan 07: 2*FEC+6*Taxotere; 3*TACE; LITT
March 07- Sept 07: Vaccination trial (phase 2, peptide based) at the UW (Seattle).
Herceptin since 2006
NED til Oct 09
Recurrence Oct 2009: to internal mammary gland since October 2009 missed on Oct and March 2010 scan.. palpable nodes in May 2010 when I realised..
Nov 2011:7 mets to lungs progressing fast failed hercp/tykerb/xeloda combo..

superior vena cava blocked: stent but face remains puffy

April 2012: Teresa Trial, randomised to TDM1
Nov 2012 progressing on TDM1
Dec 2012 blockage of my airways by tumours, obliteration of these blocking tumours breathing better but hoping for more- at mo too many tumours to count in the lungs and nodes.

Dec 2012 Starting new trial S-222611 phase 1b dual egfr her2+ inhibitor.



'Under no circumstances should you lose hope..' Dalai Lama

Last edited by fullofbeans; 05-21-2010 at 08:14 AM..
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