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TSund · 10-04-2009, 01:52 PM

Ruth has been asked if she wants to participate in this trial. She is really, really torn. She is so ready to be DONE.

As I understand it, this drug is similar to Herceptin but will cross the blood/brain barrier, unlike Herceptin. This is possibly a huge plus. Feels to me like a bigger "punch" than the AI treatment she is currently on. (will switch in 6 months from Tamaxifen to Arimidex or Femara)

Does anyone know more about this drug or the studies that have been done so far?

I even wonder if she might be better choosing this trial than to endure the Arimidex/Femara AI side effects. If she gets the diarreha she can be pretty darn sure she doesn't have the placebo. I realize they do not target the same receptors, but certainly it's the HER2 that's the much bigger issue, yes?

Thank-you for any replies.

10-04-2009, 01:52 PM	#12
TSund Senior Member Join Date: May 2007 Location: DFW area (TX) Posts: 431	Re: Neratinib Clinical Trial Ruth has been asked if she wants to participate in this trial. She is really, really torn. She is so ready to be DONE. As I understand it, this drug is similar to Herceptin but will cross the blood/brain barrier, unlike Herceptin. This is possibly a huge plus. Feels to me like a bigger "punch" than the AI treatment she is currently on. (will switch in 6 months from Tamaxifen to Arimidex or Femara) Does anyone know more about this drug or the studies that have been done so far? I even wonder if she might be better choosing this trial than to endure the Arimidex/Femara AI side effects. If she gets the diarreha she can be pretty darn sure she doesn't have the placebo. I realize they do not target the same receptors, but certainly it's the HER2 that's the much bigger issue, yes? Thank-you for any replies. __________________ Terri, spouse of Ruth, Dallas/Ft. Worth area Ruth dx 05/01/07 (age 50) Filipino multifocal, several tumors .5 -2.5 cm, large area Breast MRI showed 2 enlarged nodes, not palpable 100%ER+, 95%PR+, HER2+++ 6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage 1 year Herceptin till 6/08 MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells" now 50% ER+, PR- ??? Rads finished 1/16/08 Added Tamoxifen, Finished Herceptin 05/08 NOW is the time to appreciate life to the fullest. Last edited by TSund; 10-04-2009 at 01:56 PM..