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Becky · 02-02-2019, 09:19 PM

Prior to using herceptin, adriamycin and drugs similar to it were the gold standard for her2 positive bc. This is because it it very effective if you are also topo2 positive which about half the people who are her2 are. This is because the topo2 Gene lies very close to the her2 Gene and both get messed up and mutated. However, with herceptin, this didn't matter anymore so they moved away from those drugs. So, of they aren't going to be giving you herceptin, then this isn't a bad choice.

02-02-2019, 09:19 PM	#90
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: Treatment after Kadcyla? Prior to using herceptin, adriamycin and drugs similar to it were the gold standard for her2 positive bc. This is because it it very effective if you are also topo2 positive which about half the people who are her2 are. This is because the topo2 Gene lies very close to the her2 Gene and both get messed up and mutated. However, with herceptin, this didn't matter anymore so they moved away from those drugs. So, of they aren't going to be giving you herceptin, then this isn't a bad choice. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"