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I was also wondering that...although its quite a different story adding a cycle of Adriamycin vs. one of herceptin.
I wonder if you could get a waiver or something based on the recent findings that anthracyclines only benefit a small subset of patients and/or that the "new" standard of care in your situation is treatment with taxanes anyway. You've still had multiple chemos with the Xeloda.
They are obviously looking for a heavily pretreated population - and it's always nice to feel like you're not part of that crowd. But it can be really frustrating trying to thread the needle on trial eligibility - you feel like you're always just a bit too much...or too little for whatever they're looking for.
In studies they do have to decide on and then stick with the protocol, but sometimes there is a little bit of "wiggle" room; it might be worth pushing back and seeing if they can find a way.
Good luck on your next step, be it DM1 or something else.
chris
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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