http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum
Cyclooxygenase inhibitors suppress aromatase expression and activity in breast cancer cells.
DÃ*az-Cruz ES, Shapiro CL, Brueggemeier RW.
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.
"Thus, COX inhibitors decrease aromatase mRNA expression and enzymatic activity in human breast cancer cells in culture, suggesting that these agents may be useful in suppressing local estrogen biosynthesis in the treatment of hormone-dependent breast cancer."