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Old 06-17-2015, 06:11 AM   #1
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1960s DDT Exposure Tied to Breast Cancer Risk 50 Years Later

This is a Medscape article, which requires free registration to access:

Of interest:

Further analyses linked DDT to advanced stage at diagnosis (estimated OR, 2.2; 95% CI, 1.1 - 4.2; P = .2) and to HER2-positive tumors (estimated OR, 2.1; 95 CI, 1.0 - 4.8; P = .05).

Daughters of women with triple the amount of exposure to DDT had four times the risk of developing advanced-stage and HER2-positive breast cancer compared with daughters of women with lower levels of exposure (for late-stage: OR, 4.6; 95% CI, 1.3 - 16.5; for HER2-positive: OR, 4.6; 95% CI, 1.1 - 19.7).

Laboratory studies have provided support for these findings and suggest that DDT activates the HER2 receptor, write the authors in their article, published online June 16 in the Journal of Clinical Endocrinology and Metabolism.

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