Rama, I'm not familiar with the E57 vaccine, but the HER2 CTL vaccine trial I was in was designed to study the saftey of this vaccine in women also on Herceptin so yes, it was as an adjuvant treatment. The vaccine was trialed in an earlier group of women NOT on any other therapy, and proved safe, so the next step is testing saftey in conjunction with Herceptin. The trial is still accruing Stage III and IV volunteers; one must have No Evidence of Disease or Stable Disease, and a month out from last chemo.
There are also other trials at University of Washington involving this and other similar vaccines, so if you need more information you should feel free to contact Patty Fintak, the Research Coordinator; she's extremely helpful and will give you lots of info:
Patricia Fintak, Research Coordinator
1-206-543-6620
paf3@u.washington.edu
<3,
Lolly