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Old 04-21-2015, 09:19 AM   #18
Rolepaul
Senior Member
 
Join Date: Jan 2012
Location: Boulder Colorado as of January 2013
Posts: 389
Re: TDM1 for HER2+ brain mets reocurrence?

Nina and others started at 40 mg weekly for a four week period. This lets the easy to kill cells die and causes less of need for steroids. Then bump it to 1.6 mg/kg to get the rest of the cells. For Nina at 60 kg, 142 lbs, we went to 80 mg and then 100 mgs. Every week from February 4 2012 to July 1 2012 at 80 mg, then 100 mg every two weeks for six months, then 100 mgs every four weeks for past 28 months. So quite a bit different. The cost of the treatment is dependent upon the hospital being able to use the remaining amount of Herceptin in the vial on another patient. This can also be used for the systemic in some settings. With Nina, we went to systemic Herceptin and navelbine from March 2012 to August 2012. Then just herceptin from August 2012 to August 2014. Switched to TDM-1 August 2015 because of a hot lymph node, which then went cold by October 2014.
I have a good relationship with the treating physicians and they will run outside the lines for me.
There are people that stay inside the box, there are people that go outside the box, and there are a few of us that found if you stand on the box you get a better view. But it means that you sometimes have people throw more rocks at you.
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