HER2 Support Group Forums - View Single Post - Has anyone been on TDM-1 for more than 2 years?

phil · 09-03-2013, 10:10 AM

Lorraines' lfts are alwys a little elevated , due to drug irritation , so we are not really concerned , at least in terms of cancer . Similar to how we feel about bili. We like breaks in tx as lfts, bili drop.
I don't have her exact no's here, but Lorraines' lfts are often 55 + in one , into 80's - 90 in the other , even over 100 . we take 1 -2 week break , and they drop .
as far as brain tx, i dont know, but the emtansine is a toxic chemo , un-like the biologics like herc and avastin. so that may be a factor.
I wish they would get Marianne finished up so we can compare t dm-1 to taxanes in first line tx. the small trial just completed says t dm-1 outperforms herc/taxotere. and I wish This FDA would open up full approval for perjeta to stage ivs's . They are SO SLOWWWW, they are " killing " us , ( not intentionally , but...) and no advocacy grp speaks up.

09-03-2013, 10:10 AM	#13
phil Senior Member Join Date: Nov 2010 Posts: 393	Re: Has anyone been on TDM-1 for more than 2 years? Lorraines' lfts are alwys a little elevated , due to drug irritation , so we are not really concerned , at least in terms of cancer . Similar to how we feel about bili. We like breaks in tx as lfts, bili drop. I don't have her exact no's here, but Lorraines' lfts are often 55 + in one , into 80's - 90 in the other , even over 100 . we take 1 -2 week break , and they drop . as far as brain tx, i dont know, but the emtansine is a toxic chemo , un-like the biologics like herc and avastin. so that may be a factor. I wish they would get Marianne finished up so we can compare t dm-1 to taxanes in first line tx. the small trial just completed says t dm-1 outperforms herc/taxotere. and I wish This FDA would open up full approval for perjeta to stage ivs's . They are SO SLOWWWW, they are " killing " us , ( not intentionally , but...) and no advocacy grp speaks up.