HER2 Support Group Forums - View Single Post

vqtilley · 04-21-2015, 10:50 AM

This is fascinating. I hope you don't mind a few questions. Do I understand correctly that for the past 28 months you are combining 100 mgs of IT Herceptin every four weeks with systemic TDM-1 since August 2014, which I'd guess is administered every 3 weeks? If so, how is she doing on that combination? Is she using an Omayya reservoir for the IT? If so, can you share anything about how is that going for her? It seems like a lot of accessing - she must be worn out with it, no?

I appreciate the box analogy. I'm the stand-on-the-box type, myself, but fortunately I feel I have an excellent neuro-surgery and radiology team at the Sideman Center/Barnes-Jewish in St Louis who also seem to like standing on boxes.

04-21-2015, 10:50 AM	#19
vqtilley Member Join Date: Mar 2015 Posts: 13	Re: TDM1 for HER2+ brain mets reocurrence? This is fascinating. I hope you don't mind a few questions. Do I understand correctly that for the past 28 months you are combining 100 mgs of IT Herceptin every four weeks with systemic TDM-1 since August 2014, which I'd guess is administered every 3 weeks? If so, how is she doing on that combination? Is she using an Omayya reservoir for the IT? If so, can you share anything about how is that going for her? It seems like a lot of accessing - she must be worn out with it, no? I appreciate the box analogy. I'm the stand-on-the-box type, myself, but fortunately I feel I have an excellent neuro-surgery and radiology team at the Sideman Center/Barnes-Jewish in St Louis who also seem to like standing on boxes. __________________ Feb 2012: diagnosed with 1 cm lesion rt breast, DCIS left breast, Stage IV ER+/HER2+ Apr 2012: bilateral partial excisions; confirmed met to left proximal femur, long gamma nail inserted to stabilize femur: May 2012: radiation to femur: chemo with Trastuzumab + taxane. July 2012 thru Mar 2015: started maintenance regime Herceptin+Arimidex+Denosumab, NED May 2014: recurrence in right acetabulum: 15 fractions radiation Jan 2015: lesion in left cerebellum: resection & gamma knife treatment Mar 2015: major general progression; small mets confirmed in rt axilla, rt breast, T7 vertebra, possible met as isolated spiculated pulmonary nodule left lung[LIST][]27 Mar 2015: start Kadcyla, discontinue aromotase inhibitors; within two weeks axilla/rt breast lesions are shrinking noticeably[]18 April: resume letrozole []May: all lesions disappeared or dormant[]June - discontinue Kadcyla due to low platelets[*]Aug & Nov 2015 MRI brain/spinal scans all negative for CNS disease: no recurrence to date Fall 2015 - stereotactic radiation to lingering T3 lesion to relieve pain; 90% effective within weeks July 2019 - discontinued Letrozole due to side effects April 2020 - short course steretactic radiation to 2 cm lesion in upper left lung; subsequent scan finds it reduced Mar 2021 - 6.5 cm mass found in left lung; FISH finds it is PR-, ER- and strongly HER2+. 16 April 2021 - Resume Kadcyla.