HER2 Support Group Forums - View Single Post - towards a rational tailored approach to who should receive herceptin/lapatinib/both

Lani · 01-14-2011, 06:36 PM

Julie it may be in those people that her3 is driving the tumor or IGFR1 has substituted or many other pathways downstream of herceptin can be "revved" up in the face of her2 blockade. The tumor can also regain/increase ER and escape via the ER pathway. Have any biopsies been done on the metastasis/metastases for ER testing?

Pertumab blocks a different area of her2 and blocks her3 as well. Any chance of getting on a trial using pertuzumab? Similarly, there are TKIs under development which work against other her family members and work on the inside of the receptor (like lapatinib, but lapatinib misses her3) rather than the outside (like herceptin, erbitux, and pertuzumab)

01-14-2011, 06:36 PM	#6
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: towards a rational tailored approach to who should receive herceptin/lapatinib/bo Julie it may be in those people that her3 is driving the tumor or IGFR1 has substituted or many other pathways downstream of herceptin can be "revved" up in the face of her2 blockade. The tumor can also regain/increase ER and escape via the ER pathway. Have any biopsies been done on the metastasis/metastases for ER testing? Pertumab blocks a different area of her2 and blocks her3 as well. Any chance of getting on a trial using pertuzumab? Similarly, there are TKIs under development which work against other her family members and work on the inside of the receptor (like lapatinib, but lapatinib misses her3) rather than the outside (like herceptin, erbitux, and pertuzumab)