HER2 Support Group Forums - View Single Post - An other antiangiogenesis drug (besides Aspirin in previous post by Tom):Orlistat

Lani · 10-04-2006, 10:57 AM

As I recall it was synergistic with Herceptin. unfortunately if I remember correctly, the concentrations required could not be met with oral orlistat, as it is not absorbed (hence its effect by carrying away fat with it down the GI tract without their being absorbed also). To work it would have to be provided parenterally (IV or IM) and its effects given in such a manner have not yet been worked out from what I understand

Roche markets both drugs--so it would be a natural for them to try to market the combo against her2neu + breast cancer.

Looks like a lot of work would be needed to determine the correct dose, administration, safety, etc as the work was done on cell lines (in vitro)

10-04-2006, 10:57 AM	#2
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Dr. Javier Menendez has done work on Orlistat and her2+ breast cancer cell lines As I recall it was synergistic with Herceptin. unfortunately if I remember correctly, the concentrations required could not be met with oral orlistat, as it is not absorbed (hence its effect by carrying away fat with it down the GI tract without their being absorbed also). To work it would have to be provided parenterally (IV or IM) and its effects given in such a manner have not yet been worked out from what I understand Roche markets both drugs--so it would be a natural for them to try to market the combo against her2neu + breast cancer. Looks like a lot of work would be needed to determine the correct dose, administration, safety, etc as the work was done on cell lines (in vitro)