Hi Chelee, I would bet that it is the SALINE that has the expiration date. When my nurses mix my Herceptin, again after I am in the chair, it is mixed from a small vial and mixed with a bag of saline. I would bet that that expiration only aplies to the saline (which I'm sure is fine) and that your Herceptin is WELL within the expiration date. If I evered wondered about anything like this, I would just flat out ask my nurse. Hey, they work for ME, right?