HER2 Support Group Forums - View Single Post - COX2 and BC a cumulative knowledge thread

StephN · 12-19-2007, 02:53 PM

Thanks for this thread, R.B.

I only just discovered it.

When I was pronounced NED after my extensive liver mets, my med onc told me that he wanted me to take Celebrex as he was interested in inhibiting COX2. I took that for almost three years, until the reports came out on the side effects.

The reason he recommended a COX2 inhibitor was that at that time all this research was just beginning but there was anecdotal evidence that a COX2 inhibitor was effective against prostate cancers. So, I have sort of put that out of my mind in the meantime, but glad to see the importance has been made clear now.

I wonder if I should be back on some form of COX2 inhibitor??

12-19-2007, 02:53 PM	#16
StephN Senior Member Join Date: Nov 2004 Location: Misty woods of WA State Posts: 4,128	Thanks for this thread, R.B. I only just discovered it. When I was pronounced NED after my extensive liver mets, my med onc told me that he wanted me to take Celebrex as he was interested in inhibiting COX2. I took that for almost three years, until the reports came out on the side effects. The reason he recommended a COX2 inhibitor was that at that time all this research was just beginning but there was anecdotal evidence that a COX2 inhibitor was effective against prostate cancers. So, I have sort of put that out of my mind in the meantime, but glad to see the importance has been made clear now. I wonder if I should be back on some form of COX2 inhibitor?? __________________ "When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau Live in the moment. MY STORY SO FAR ~~~~ Found suspicious lump 9/2000 Lumpectomy, then node dissection and port placement Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR - Adriamycin 12 weekly, taxotere 4 rounds 36 rads - very little burning 3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED! 2003 & 2004 no active disease - 3 weekly Herceptin + Zometa Jan 2005 two mets to brain - Gamma Knife on Jan 18 All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying Continue as NED while on Herceptin & quarterly Zometa Fall-2006 - off Zometa - watching one small brain spot (scar?) 2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava 2008 - Brain and body still NED! Port removed and scans in Dec. Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011 STILL NED everywhere in Feb 2014 - on wing & prayer 7/14 - Started twice yearly Zometa for my bones Jan. 2015 checkup still shows NED 2015 Neuropathy in feet - otherwise all OK - still NED. Same news for 2016 and all of 2017. Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.