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i think the answer is, if one is going to be positive for Her2 you want it strongly positive. I believe the higher the FISH score the better the Herceptin works. That is my opinion and i bet there is evidence somewhere out there for that. I was 3+ on my first test, then i did a FISH test and it was 10. That's pretty high. I'm 2 years out having 34 positive nodes and took one year Herceptin. The question about shrinking the tumor first has been proven to be better. MD anderson did a study and showed this was better. The theory is to shrink the tumor and you have less to take out. The only bad side to that is i don't think you get the axillary dissection surgery so you really don't know if there is any positive nodes. If she had a pet scan and no positive nodes, that is a good thing.
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