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donocco · 10-18-2015, 04:09 PM

I did a bit of Researchbut Becky gave you an excellent answer. It seems that Er-/PR+ is a very rare subtype and not always reproducible.

There can be ER+/PR+ and ER+/PR-. It seems the first kind responds considerably better to anti-hormonal treatment. At first it was difficult seeing any info about the treatment of ER-/PR+ with antihormonal drugs so I went to pub-med and put "treatment of progesterone positive breast cancer in the search box. If you look at the 10th entry there is a statement at the end of the abstract that says" ER-/PR+ breast cancer responds better to antihormonal therapy than ER+/PR- breast cancer. It seems an Aromatase Inhibitor is acceptable treatment.

Paul

10-18-2015, 04:09 PM	#4
donocco Senior Member Join Date: Oct 2013 Posts: 474	Re: Progesterone Positive, Estrogen Negative I did a bit of Researchbut Becky gave you an excellent answer. It seems that Er-/PR+ is a very rare subtype and not always reproducible. There can be ER+/PR+ and ER+/PR-. It seems the first kind responds considerably better to anti-hormonal treatment. At first it was difficult seeing any info about the treatment of ER-/PR+ with antihormonal drugs so I went to pub-med and put "treatment of progesterone positive breast cancer in the search box. If you look at the 10th entry there is a statement at the end of the abstract that says" ER-/PR+ breast cancer responds better to antihormonal therapy than ER+/PR- breast cancer. It seems an Aromatase Inhibitor is acceptable treatment. Paul