HER2 Support Group Forums - View Single Post - Is prevention of her2+ brain mets around the corner? Oral TKI Pazopanib

Lani · 04-18-2013, 10:55 AM

It has been approved for renal cell carcinoma and soft tissue sarcoma by the U.S. Food and Drug Administration.

Thus it would only be "off-label use"

Please note, I am not saying this has been shown definitively to prevent her2+ brain mets while being both safe and efficacious. I am saying it is looking like it might turn out to help prevent her2+ brain mets and that if prospective blinded clinical trials show it to be(and that is still a big IF) , it shouldn't take too long to be approved as it is already approved for other indications.

04-18-2013, 10:55 AM	#7
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: Is prevention of her2+ brain mets around the corner? Oral TKI Pazopanib It has been approved for renal cell carcinoma and soft tissue sarcoma by the U.S. Food and Drug Administration. Thus it would only be "off-label use" Please note, I am not saying this has been shown definitively to prevent her2+ brain mets while being both safe and efficacious. I am saying it is looking like it might turn out to help prevent her2+ brain mets and that if prospective blinded clinical trials show it to be(and that is still a big IF) , it shouldn't take too long to be approved as it is already approved for other indications.