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chrisy · 02-05-2009, 02:43 PM

Yes, Sheila, it is chemo brain. I've not been on Ixempra, I had Tykerb + Avastin (remember the tissue challenged hotel room!)

However I do agree with keeping a her2 targeted agent in the mix if possible. Eric, unless that is CAUSING the toxicity (which it probably isn't), usually the recommendation is to add chemo to the herceptin. Getting positivity rechecked would also be prudent tho. I don't remember what all Caryn has been on in trials, but remember it wasn't the herceptin piece that caused the issues with the DM1 trial - it was the DM1 piece.

Ixempra has been getting a lot of good results in taxane refractory bc, so it would be a good choice. It does also have some liver tox so you'd have to watch that. It's a proven therapy vs. some of the early trial drugs, too.

hang in there
chris

02-05-2009, 02:43 PM	#7
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	Yes, Sheila, it is chemo brain. I've not been on Ixempra, I had Tykerb + Avastin (remember the tissue challenged hotel room!) However I do agree with keeping a her2 targeted agent in the mix if possible. Eric, unless that is CAUSING the toxicity (which it probably isn't), usually the recommendation is to add chemo to the herceptin. Getting positivity rechecked would also be prudent tho. I don't remember what all Caryn has been on in trials, but remember it wasn't the herceptin piece that caused the issues with the DM1 trial - it was the DM1 piece. Ixempra has been getting a lot of good results in taxane refractory bc, so it would be a good choice. It does also have some liver tox so you'd have to watch that. It's a proven therapy vs. some of the early trial drugs, too. hang in there chris __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure