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Anne,
Here's the thing: just because your primary tumor is not HER2 positive that doesn't mean that the mets aren't. Most recent research has shown that over 50% of mets are HER2 positive and that HER2 status and hormonal status can change with mets.
I also question the "poorer prognosis" argument. If your mets are HER2 positive, have been identified as that and you are on herceptin, then I think you have a survival advantage over HER2 negative. Anyone else want to weigh-in on this one?
Al
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