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Old 09-25-2008, 11:59 AM   #9
chrisy
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Join Date: Sep 2005
Location: Central Coast, CA
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Hard to say...I was just reading about Dr. Judah Folkman, the man who pioneered the understanding of angiogenesis and it's role in cancer growth. He was ridiculed for 25 years but never gave up on his research...which eventually led to the acceptance of his theory and subsequent targeting of these pathways with Avastin and other drugs...

All I can say is, it takes way too long and too many valid ideas probably end up on the side of the road waiting for acceptance and funding.

By the way, tho, the book I was reading this in was actually about how you can improve the "terrain" in your body to improve your own immune response and attack cancer's weaknesses. Primarily through diet and lifestyle changes. One point of the Judah Folkman story was that the agents that disrupt/prevent antiogenesis are ALSO available in many of the foods we eat...and you don't have to wait for the Avastins to come out.

Which comes full circle back to some of the earlier discussion on your topic - how could we mimic these effects through dietary interventions? That might be an interesting conversation to have with Dr. Yamamoto!
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure

Last edited by chrisy; 09-25-2008 at 12:05 PM..
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