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runtolive · 03-06-2009, 10:02 AM

julie/ tdm1 is herceptin + a toxin... a maytansine derivative attached via a linker to the herceptin..

HERceptin is an antibody which directly targets HER2+++ CANCERS. once herceptin locates the tumors / mets/ etc and attaches to them. the toxin enters/internalizes into the tumor.. and releases its potent poison into the tumor and kills the tumor. IN ABOUT HALF THE PATIENTS, hopefully preventing recurrences. eventually tdm1 will be the gold standard/ replacing herceptin entirely

run

03-06-2009, 10:02 AM	#11
runtolive Senior Member Join Date: Nov 2007 Posts: 210	julie/ tdm1 is herceptin + a toxin... a maytansine derivative attached via a linker to the herceptin.. HERceptin is an antibody which directly targets HER2+++ CANCERS. once herceptin locates the tumors / mets/ etc and attaches to them. the toxin enters/internalizes into the tumor.. and releases its potent poison into the tumor and kills the tumor. IN ABOUT HALF THE PATIENTS, hopefully preventing recurrences. eventually tdm1 will be the gold standard/ replacing herceptin entirely run