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EPA and DHA act as Cox 2 blockers.
Genistein acts as a Cox blocker.
Genistein acts synergistically with DHA.
AA the daughter omega six increased invasiveness as one would expect.
Genistein with omega threes uprates PPAR gamma which feature is in BC but I cannot remember how - or what relation this bears to omega six. So a ?? for the moment.
Genistein is an active ingredient in soy. There is much discussion if soy is good or bad.
So on balance more ticks for omega threes, crosses for omega six and a maybe for genestein via soy.
RB
Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells.
Horia E, Watkins BA.
Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907, USA.
Abstract
"The n-3 PUFA and genistein alone lowered PGE(2) concentration, and genistein in combination with AA reversed the high level of this prostanoid in cell cultures enriched with AA. The degree of cell invasiveness was reversed by genistein in cell cultures treated with AA and further reduced in those given DHA. The n-3 PUFA, in contrast to AA, reduced COX-2 and NFkappaB expression. Genistein combined with AA reversed the effects of AA alone on the expression of COX-2 and NFkappaB. All three fatty acids increased the expression of PPARgamma in the cells only when combined with genistein. Our results support the premise that DHA and genistein exert complementary actions whilst genistein is antagonistic to AA for controlling PGE(2) production as well as invasiveness of MDA-MB-231 cells in culture by modulating the level of NFkappaB expression."
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