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gdpawel · 01-06-2013, 06:30 PM

There can be a myriad of signaling pathways. The simple inhibition at one node in a cascade of signaling pathways will absolutely change the dynamic and redirect up and down stream signals that ultimately overcome inhibition. They are forever trying to develop strategies to control these resistance mechanisms, however, we find that simple genomic analyses underestimate the complexity of human systems.

The themes that emanated at this year's American Association of Cancer Research (AACR) meeting included a renewed focus on the biochemistry of metabolism, a clear progress in the field of tumor immunology and the growing recognition that human tumors exist as microenvironments and not isolated single cells. The cross-talk between receptors can be abrogated and upstream/downstream signaling can be squelched in many ways.

More focus should be on human tumor aggregates (microspheroids) isolated directly from patients as the most accurate model for chemotherapy selection. The capacity to study human tumor microenvironments enables discovery work on the most sophisticated classes of compounds that influence cell signaling at all levels.

01-06-2013, 06:30 PM	#3
gdpawel Senior Member Join Date: Aug 2006 Location: Pennsylvania Posts: 1,080	There can be a myriad of signaling pathways There can be a myriad of signaling pathways. The simple inhibition at one node in a cascade of signaling pathways will absolutely change the dynamic and redirect up and down stream signals that ultimately overcome inhibition. They are forever trying to develop strategies to control these resistance mechanisms, however, we find that simple genomic analyses underestimate the complexity of human systems. The themes that emanated at this year's American Association of Cancer Research (AACR) meeting included a renewed focus on the biochemistry of metabolism, a clear progress in the field of tumor immunology and the growing recognition that human tumors exist as microenvironments and not isolated single cells. The cross-talk between receptors can be abrogated and upstream/downstream signaling can be squelched in many ways. More focus should be on human tumor aggregates (microspheroids) isolated directly from patients as the most accurate model for chemotherapy selection. The capacity to study human tumor microenvironments enables discovery work on the most sophisticated classes of compounds that influence cell signaling at all levels.