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agness · 10-06-2015, 02:56 AM

HER2-specific T cells As An Immunotherapy In HER2-Positive Sarcoma (2015)
http://immuno-oncologynews.com/2015/...itive-sarcoma/

Dr. Gottschalk explained that T cells have been used as a cancer immunotherapy over the last 10 to 15 years, but there not been many CAR T-cell therapy studies for solid tumors have been developed so far, mainly for those expressing the HER2 protein. Dr. Gottschalk added that HER2-CAR T cells are safe in high doses, and because HER2 is expressed in a wide variety of tumors, this strategy can be applied to many patients. Dr. Gottschalk added that “If you look at the history of cancer therapy, there are few examples of ‘magic bullets’ that can cure cancer alone.” As such, combining HER2-CAR T cells with other types of cancer therapeutics can prove efficient in the future of cancer research.

10-06-2015, 02:56 AM	#2
agness Senior Member Join Date: Aug 2014 Location: Seattle, WA Posts: 285	Re: HER2 and Immunotherapy Studies for reference HER2-specific T cells As An Immunotherapy In HER2-Positive Sarcoma (2015) http://immuno-oncologynews.com/2015/...itive-sarcoma/ Dr. Gottschalk explained that T cells have been used as a cancer immunotherapy over the last 10 to 15 years, but there not been many CAR T-cell therapy studies for solid tumors have been developed so far, mainly for those expressing the HER2 protein. Dr. Gottschalk added that HER2-CAR T cells are safe in high doses, and because HER2 is expressed in a wide variety of tumors, this strategy can be applied to many patients. Dr. Gottschalk added that “If you look at the history of cancer therapy, there are few examples of ‘magic bullets’ that can cure cancer alone.” As such, combining HER2-CAR T cells with other types of cancer therapeutics can prove efficient in the future of cancer research. __________________ Dx 2/14 3b HER2+/HR- left breast, left axilla, internal mammary node (behind breast bone). Neoadjuvant TCHP 3/14-7/2. PCR 8/14 LX and SND. 10/21-12/9 Proton therapy to chest wall. Dx 7/20/15 cerebellar met 3.5x5cm HER2+/HR-/GATA3+ 7/23/15 Craniotomy. 7/29/15 bone scan clear. 8/3/15 PET clean scan. LINAC SRS (5 fractions) Sept 2015. 9/17/15 CSF NED, 9/24/15 CSF NED, 11/2/15 CSF NED. 10/27/15 atypical uptake in right cerebellum - inflammation? 12/1/15 Leptomeningeal dx. Starting IT Herceptin. 1/16 - 16 fractions of tomotherapy to cerebellum, break of IT Herceptin during rads, resume at 100 mg weekly 3/2016 - stable scan 5/2016 stable scan 7/2016 pseudoprogression? 9/2016 more LM, start new chemo protocol and IV therapy treatment with HBOT 11/2016 Cyberknife to temporal lobe, HBOT just prior 12/2016 - lesions starting to show shrinkage 8/2017 - Stable since Dec 2016. Temporal lobe lesion gone. Using TCM, naturopathic oncology, physical therapy, chiro, massage, medical qigong, and energetic healing modalities in tandem. Stops at nothing. Mother of 2 boys - ages 7 and 10 (8/2017) and a lovely partner with lots to live for.