HER2 Support Group Forums - View Single Post - COX2 and BC a cumulative knowledge thread

R.B. · 11-05-2007, 06:17 PM

http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum
Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells.
Tari AM, Simeone AM, Li YJ, Gutierrez-Puente Y, Lai S, Symmans WF.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. atari@mdanderson.org

"We speculate that high levels of COX-2 induce drug resistance in ERalpha-positive breast tumors, thus reducing the survival rate of patients with such tumors."

"Here we report the novel findings that COX-2 uses PGE2 to stimulate the activities of protein kinases A and C to induce selectively tamoxifen and 4-HPR resistance in ERalpha-positive breast cancer cells."

11-05-2007, 06:17 PM	#6
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	COX2 uses PGE2 to induce tamoxifen resistance http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells. Tari AM, Simeone AM, Li YJ, Gutierrez-Puente Y, Lai S, Symmans WF. Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. atari@mdanderson.org "We speculate that high levels of COX-2 induce drug resistance in ERalpha-positive breast tumors, thus reducing the survival rate of patients with such tumors." "Here we report the novel findings that COX-2 uses PGE2 to stimulate the activities of protein kinases A and C to induce selectively tamoxifen and 4-HPR resistance in ERalpha-positive breast cancer cells."