I couldn't find the other treads on the issue but my mom was on this and she did have the hand foot syndrome briefly. I suspect the dirty feet look(dark/red?) you have is the beginning of this. With mom, it started with the look, progressed to feeling warm, then became a problem. Basically, the Xeloda has a way of leaking into healthy tissues and goes to the extremities.
Things that seem to help:
Udder Cream (available at Wal-Mart) Note: apply liberally but GENTLY. Vigorous rubbing can aggravate things. Apply a few times throughout day. Good to goop it on at night and wear cotton socks or gloves to keep it there.
B6 supplement, 200mg/day
" The addition of pyridoxine (
200 mg/day) for ameliorating the symptoms of CAP-induced HFS allows for the administration of higher doses of CAP"
Topical Henna, purchase here:
www.castleart.com
discussed here:
http://xelodasideeffects.blogspot.com/
Interesting anecdote: "Henna is a natural antiseptic and the chemical in henna fills the skin cell thus it can keep hands from cracking . Field workers in India would dig small recesses in the dirt fill with henna & water ans dip their hands & feet in the mix to help prevent the skin from cracking and keep other nasty bacteria away."
Mom also used generic neosporin from Walgreens for splits.
Staying off feet as much as possible until things calm down may help.
I would suggest trying all the above before approaching docs since they may only offer dose reduction.
I don't know about nails splitting although mom noticed some odd growth patterns.
I just came across this lengthy article about 5FU (active component of Xeloda) which gives a great overview of where Xeloda came from and hints at newer variations on the way (S-1)
http://theoncologist.alphamedpress.o...t/full/7/4/288