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Christine MH-UK · 08-22-2006, 11:04 AM

Great find, Tom. I thought I had posted something on CXCR4 before, so I did a search and lo and behold it is highly relevant to HER2. I remember I did some later research on this and CXCR4 turns out to play a major role in AIDS as well.

"Study Finds HER2-positive Breast Cancer Invades Organs Due To Fatal Chemical Attraction"

"Researchers at The University of Texas M. D. Anderson Cancer Center have solved the mystery of why an aggressive form of HER2-positive breast cancer travels readily to a few key organs - lungs, liver and bone - where it then establishes new tumors."

The research shows that metastatic HER2 BC cells have too many CXCR4 receptors and, as a result, tend to migrate to certain organs that produce an attracting substance. Efforts are underway to produce a drug that will block CXCR4.

08-22-2006, 11:04 AM	#2
Christine MH-UK Senior Member Join Date: Sep 2005 Posts: 414	Here's one I made earlier! Great find, Tom. I thought I had posted something on CXCR4 before, so I did a search and lo and behold it is highly relevant to HER2. I remember I did some later research on this and CXCR4 turns out to play a major role in AIDS as well. "Study Finds HER2-positive Breast Cancer Invades Organs Due To Fatal Chemical Attraction" "Researchers at The University of Texas M. D. Anderson Cancer Center have solved the mystery of why an aggressive form of HER2-positive breast cancer travels readily to a few key organs - lungs, liver and bone - where it then establishes new tumors." The research shows that metastatic HER2 BC cells have too many CXCR4 receptors and, as a result, tend to migrate to certain organs that produce an attracting substance. Efforts are underway to produce a drug that will block CXCR4.