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Re: Kadcyla Side Effects
I asked my med onc and he said transfer across the BBB is variable and not fully understood, so even though Kadcyla is a large molecule that normally doesn't pass through that doesn't mean none is. Radiation to the brain or brain surgery, which I've had, can make the BBB more permeable, for example. But I'm still not feeling too secure about this on Kadcyla. Platelets have plunged to 50,000 on day 7, btw.
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Feb 2012: diagnosed with 1 cm lesion rt breast, DCIS left breast, Stage IV ER+/HER2+
Apr 2012: bilateral partial excisions; confirmed met to left proximal femur, long gamma nail inserted to stabilize femur:
May 2012: radiation to femur: chemo with Trastuzumab + taxane.
July 2012 thru Mar 2015: started maintenance regime Herceptin+Arimidex+Denosumab, NED
May 2014: recurrence in right acetabulum: 15 fractions radiation
Jan 2015: lesion in left cerebellum: resection & gamma knife treatment
Mar 2015: major general progression; small mets confirmed in rt axilla, rt breast, T7 vertebra, possible met as isolated spiculated pulmonary nodule left lung[LIST][*]27 Mar 2015: start Kadcyla, discontinue aromotase inhibitors; within two weeks axilla/rt breast lesions are shrinking noticeably[*]18 April: resume letrozole [*]May: all lesions disappeared or dormant[*]June - discontinue Kadcyla due to low platelets[*]Aug & Nov 2015 MRI brain/spinal scans all negative for CNS disease: no recurrence to date
Fall 2015 - stereotactic radiation to lingering T3 lesion to relieve pain; 90% effective within weeks
July 2019 - discontinued Letrozole due to side effects
April 2020 - short course steretactic radiation to 2 cm lesion in upper left lung; subsequent scan finds it reduced
Mar 2021 - 6.5 cm mass found in left lung; FISH finds it is PR-, ER- and strongly HER2+.
16 April 2021 - Resume Kadcyla.
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