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Angel,
To your point about toxicity, I thought this excerpt from Novartis' Femara web site for "Health Care Professionals outside the United States"
was relevant:
"No significant differences were observed on global physical and mental summary scores, suggesting that overall, letrozole did not worsen quality of life relative to placebo. Treatment differences in favor of placebo were observed in patients' assessments with particularly the measures of physical functioning, bodily pain, vitality, sexual and vasomotor items. Although statistically significant, these differences were not considered clinically relevant." (emphasis added)
If you'll pardon my expression, coming from the drug manufacturer, this is a real kick in the pants.
Hopeful
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