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kk1 · 03-27-2013, 09:36 AM

Ann,

First I just want to say you're AWESOME. We have never met, but I love the way you write with such compassion, thoughtfulness, and intelligence.

So one thing I notice in your profile is the ER+ issue. Are you on an AI? All the latest research shows that it is really important to block both pathways at the same time. Certainly was true in my case....every time estrogen began to rise the big C came out of hiding too. We tried different approaches over the years to block estrogen, but finally got rid of the internal parts and have been stable and NED since, of course also combined with an AI multiple HER2 blockade plus the zometa.

Like you I grew a bunch of scientists. I also never thought I would see either of them even graduate from grammar school. This year the first one graduated from University in December, and is admitted and heading to graduate school in the fall. I think I might even get to see the second graduate University in another 2 years. Keep the faith, it is possible.

k

03-27-2013, 09:36 AM	#8
kk1 Senior Member Join Date: Sep 2005 Posts: 182	Re: Question for liver metsters Ann, First I just want to say you're AWESOME. We have never met, but I love the way you write with such compassion, thoughtfulness, and intelligence. So one thing I notice in your profile is the ER+ issue. Are you on an AI? All the latest research shows that it is really important to block both pathways at the same time. Certainly was true in my case....every time estrogen began to rise the big C came out of hiding too. We tried different approaches over the years to block estrogen, but finally got rid of the internal parts and have been stable and NED since, of course also combined with an AI multiple HER2 blockade plus the zometa. Like you I grew a bunch of scientists. I also never thought I would see either of them even graduate from grammar school. This year the first one graduated from University in December, and is admitted and heading to graduate school in the fall. I think I might even get to see the second graduate University in another 2 years. Keep the faith, it is possible. k __________________ KK1 April 2004 de novo metastatic left breast 1.5cm her2++,er+/pr+ with 2 small liver mets weekly taxotere,herceptin, xeloda Sept 2004 NED-3 herceptin, zoladex,aromasin Dec 2006 recurrence in liver Feb. 2007 liver resection left lobe removed-herceptin, zoladex, switch to Arimidex NED 16 months added zometa May 2008 new lesion in liver 15mm Tykerb/Xeloda/Herceptin July 2008 stable...yeah! Sept 2008 NED again !!! Jan 2009 fell off the wagon again spot back in the liver and fell out of menopause. Feb 2009 RFA and 2nd liver resection to remove spot ---back on the NED wagon again continue Tykerb, Herceptin. March 2009- oophrectomy added Femara and bi-annual Zometa May 2009- scans clear but suspect lung nodule June 2009- Lung VAT wedge resection to remove nodule---fungus ball not cancer!! phew Aug 2009- NED Nov 2009-scans again clear YAHOO! March 2010- scans clear continue Tykerb, Herceptin, Femara, Zometa Q6mo Nov 2009-Nov 2019 scans clear done every 6 months Feb 2020 - Fell out of the NED wagon hard! single liver lesions and large infect cyst. 3 weeks in ICU. March 2021- 5 cycles perjeta, herceptin, navelbine. lesion stable. June 2021 - 3rd liver resection to remove single liver lesion. Continued perjeta, herceptin. Nov. 2021- PET scan show 5 hot nodes near liver. 9 cycles Kadcyla June 2021- PET scan shows progression. nodes size unchanged but even more SUV uptake. July 2021- start ENHERTU Last edited by kk1; 03-27-2013 at 09:38 AM..