HER2 Support Group Forums - View Single Post

Becky · 10-18-2015, 02:05 PM

The bigger issue is that in some staining, especially to determine ER status, 2/3 s of ER negative but PR positive tumors are actually ER positive, even if only a little bit. As such, aromatase inhibitors work well on PR positive tumors. Since your bc returned in the bones, you should definitely give an AI a whirl. They may very well help you tremendously. If they don't and you have side effects, you can give it up. Can you send your slides elsewhere for a pathology look?

I am 50% er positive and PR negative. I sent my slides to Sloan Kettering and they said my tumor was 50% ER AND 30 % PR. Who knows but big cancer centers probably make less mistakes since they do the test so many times in a day.

10-18-2015, 02:05 PM	#3
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: Progesterone Positive, Estrogen Negative The bigger issue is that in some staining, especially to determine ER status, 2/3 s of ER negative but PR positive tumors are actually ER positive, even if only a little bit. As such, aromatase inhibitors work well on PR positive tumors. Since your bc returned in the bones, you should definitely give an AI a whirl. They may very well help you tremendously. If they don't and you have side effects, you can give it up. Can you send your slides elsewhere for a pathology look? I am 50% er positive and PR negative. I sent my slides to Sloan Kettering and they said my tumor was 50% ER AND 30 % PR. Who knows but big cancer centers probably make less mistakes since they do the test so many times in a day. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"