HER2 Support Group Forums - View Single Post - Endocrine Response Enhanced in ER+/PR+ Tumors

Becky · 11-10-2006, 10:49 AM

A few of these names are ones I recognize but have to check when I get home. I do know all about PR- and tamoxifen resistance (and this was instrumental in deciding to get my ovaries removed to use Arimidex. The Herceptin/Arimidex combo data helped me convince my onc to give me 5 extra (every 3 week) Herceptin treatments so I could be on the combination one year (hence about 16 months of Herceptin versus one year). Everyone I have ever talked to about the ER+/PR- pathology say it is worse if you are not Her2+ as well. Data indicates that ER+/PR-/Her2- strongly indicateds Her1+ (aka EGFR) whereas with Her2+ it may well not be Her1+ as well. All have indicated that it is better for either hormone receptor to be positive rather than both be negative (as it is a pathway that has treatment options).

Thanks for your kind words and knowledge.

Becky

11-10-2006, 10:49 AM	#6
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	A few of these names are ones I recognize but have to check when I get home. I do know all about PR- and tamoxifen resistance (and this was instrumental in deciding to get my ovaries removed to use Arimidex. The Herceptin/Arimidex combo data helped me convince my onc to give me 5 extra (every 3 week) Herceptin treatments so I could be on the combination one year (hence about 16 months of Herceptin versus one year). Everyone I have ever talked to about the ER+/PR- pathology say it is worse if you are not Her2+ as well. Data indicates that ER+/PR-/Her2- strongly indicateds Her1+ (aka EGFR) whereas with Her2+ it may well not be Her1+ as well. All have indicated that it is better for either hormone receptor to be positive rather than both be negative (as it is a pathway that has treatment options). Thanks for your kind words and knowledge. Becky