HER2 Support Group Forums - View Single Post - Risk of Recurrent Disease in HER2-Positive Patients

Rich66 · 03-11-2010, 12:30 PM

More support for the Her2/ER crosstalk concept.
The really interesting aspect (missing from the discussion) of this is that there is more than a suggestion that the actual ER and Her2 status can essentially change after extended therapy. So..someone with a Her2+/ER- biopsy may get benefit from ER therapies after the Herceptin and/or Tykerb therapies "upregulate" the ER side.

The other more obvious bit here is that Fulvestrant needs to be made available in adjuvant.

(Psst! Green tea is thought to inhibit both Her2 and ER)

03-11-2010, 12:30 PM	#3
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: Risk of Recurrent Disease in HER2-Positive Patients More support for the Her2/ER crosstalk concept. The really interesting aspect (missing from the discussion) of this is that there is more than a suggestion that the actual ER and Her2 status can essentially change after extended therapy. So..someone with a Her2+/ER- biopsy may get benefit from ER therapies after the Herceptin and/or Tykerb therapies "upregulate" the ER side. The other more obvious bit here is that Fulvestrant needs to be made available in adjuvant. (Psst! Green tea is thought to inhibit both Her2 and ER) __________________ Mom's treatment history (link)