[annettchen]

I'm also early on, but thought I'd reply anyway for what it's worth.
I have bone mets, went thru 6 cycles of THP and am now on Herceptin and Perjeta, plus Xgeva. I continue to work full time, but am lucky because I started working from the home office prior to my diagnosis in March this year.

So far, I think the impact on work is not big - some more doctors appointments than other people, and for a while I was not able to travel for work, but this is on the way to resolve. I have to say, though, that my boss has been absolutely amazing all thru this - he really tries to work around whatever limitations there are, and this approach has been profitable for both sides so far.

Side effects of Herceptin / Perjeta on their own are WAY less than with the Taxotere. So far just some big D, but easily manageable with occasional Immodium. Some bone and joint pain (but I still go horseback riding 3 times a week, and move as much as I can, as that makes me feel better). Some itch. But really - nothing to write home about.

I intend to continue working as long as I can - not only for financial reasons, but also because it helps me keep my sanity and instills some much needed normalcy into our family life...

Overall I think it depends on the amount of effects or side effects you experience, and also on the type of work... I'm a "pencil pusher", so if I don't function 100%, no one will come to harm from it, and there's not much physical strength needed for what I do...