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Old 01-13-2015, 07:21 AM   #22
Debbie L.
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Join Date: Jul 2006
Posts: 463
Re: failed reconstruction following prophylactic mastectomy

To clarify about my post about infection, in case you don't read the book (Commotion in the Blood): Although Coley did seem to have a few successes, mostly he (and others trying various similar approaches) did not meet with success. Plus some people died from the infections he induced. His methods, by today's standards, were quite primitive of course (late 1800s/early 1900s). Still, there was enough of a hint of "something there" to be intriguing. Various people, including Coley, continued to try versions of his approach until mid-century, when radiation and chemotherapy began to find success, and interest in immunotherapy waned, at least for awhile.

So it was PURE speculation for me to wonder if the raging infection I had made any difference to my outcome. I don't remember Coley's exact success rate but it was small. Still, if this interests you, I highly recommend the book -- it's an easy and interesting read. A follow-up to it would be "The Transformed Cell" by Steven Rosenberg, mostly about the efforts in the later 1900s, to "use" the immune system to stop cancer. It's a little more technical but even if you skip the complicated parts, you'll get the gist. Those efforts, too, were primitive -- compared to what's known and what's going on today. Although many ideas of that time seemed to hold great promise, almost none were successful.

So I'm throwing a wet blanket on my post, not wanting to mislead. Like I said, random, rambling speculation only.

Debbie Laxague
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3/01 ~ Age 49. Occult primary announced by large (6cm) axillary node, found by my husband.
4/01 ~ Bilateral mastectomies (LMRM, R elective simple) - 1.2cm IDC was found at pathology. 5 of 11 axillary nodes positive, largest = 6cm. Stage IIIA
ERPR 5%/1% (re-done later at Baylor, both negative at zero).
HER2neu positive by IHC and FISH (8.89).
Lymphovascular invasion, grade 3, 8/9 modified SBR.
TX: Control of arm of NSABP's B-31 adjuvant Herceptin trial (no Herceptin, inducing a severe case of Herceptin-envy): A/C x 4 and Taxol x 4 q3weeks, then rads. Raging infection of entire chest after small revision of mastectomy scar after completing tx (significance unknown). Arimidex for two years, stopped after second pathology opinion.
2017: Mild and manageable lymphedema and some cognitive issues.
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