[DeenaH]

I found out a week ago Friday that my lung mets have progressed. I have been on navelbine, herceptin and tykerb. I had significant regression on my first 2 scans post navelbine, so this progression was a surprise to me. In June I did a chemosensitivity assay, which was why I was on that combo. Now it is decision time again, and this time around things aren't as clear to me as they have been in the past. That is so scary! So, I could really use some help brainstorming from my fellow cancer sisters.

According to my assay, my next best option (from a sensitivity and toxicity standpoint) is everolimus/Herceptin. I got my UCSF onc to prescribe, but my insurance denied it. I plan to fight that, but could use any input from anyone who has been through that process.

Another option is Xeloda/Tykerb. My concern with this is that I am already fighting diarrhea. I've been having problems for months and it landed my in the hospital in august. Currently I bleed with every BM. Adding xeloda would make it worse. But, if I must, I must!

My assay showed resistant to Carbo/Gemzar, which is something my local onc is suggesting. I won't do it. At least not now. My marrow is so beat up from the navelbine and I really feel it needs a break.

In a few months, I may be eligible for the MM-302 trial at UCSF. I might join you, Courtney!!

Any other suggestions? I wish there were a TDM-1 trial I could do. If only that were available now! Darn FDA!!

Thanks for any input. I feel pretty good physically since I am now 2 weeks post navelbine. Isn't it strange how we feel better without treatment, yet sicker with the cancer?