I have not had the brown spots on my ankles up to now but Herceptin and Aredia are the only 2 drugs I am getting. Yes I get an echo every 6 mo, last one was perfect. As far as other symptoms, it could be from other drugs that you are being given. My onc is so good about discussing anything that is on my mind. I feel so lucky to have such a wonderful dr. Good luck to you and keep in touch to let me know how you are progressing. If your heart problems get worse, go see a cardiologist, don't wait for him to send you.
ginkott1@aol.com